Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity

Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity.

Toxicity resulting from excessive intra-synaptic serotonin, historically referred to as serotonin syndrome, is now understood to be an intra-synaptic serotonin concentration-related phenomenon. Recent research more clearly delineates serotonin toxicity as a discreet toxidrome characterized by clonus, hyper-reflexia, hyperthermia and agitation. Serotonergic side-effects occur with serotonergic d...

Substituted quinolines as monoamine oxidase inhibitors and analgesics.

Linezolid-induced serotonin toxicity in a patient not taking monoamine oxidase inhibitors or serotonin receptor antagonists.

Linezolid is an oxazolidinone antibiotic with weak monoamine oxidase (MAO) type A and MAO type B inhibitory effects. Linezolid has been associated with serotonin toxicity when used concomitantly with multiple medications that are known to increase serotonin concentrations. We report the case of a 65-year-old woman with signs and symptoms of serotonin toxicity following administration of linezol...

Rediscovering monoamine oxidase inhibitors.

comparisons be possible. The real differences in surgical mortality that do exist between surgeons and centres may teach important lessons. One study compared mortality between a teaching hospital and its adjacent district hospital and led to a proper intensive care unit being provided in the district hospital. 14 The confidential inquiry into perioperative deaths emphasised the value of regula...

[Monoamine oxidase inhibitors].

Monoamine Oxidase Inhibitors DEAR SIR, Dr Pare's article on †̃¿ The Present Status of Monoamine Oxidase Inhibitors' is one of a genre that marks the renaissance of these drugs (Murphy et al, 1984; White & Simpson, 1985). This is understandable given that the †̃¿ second generation' compounds are less exciting than hoped, that early use of phenelzine was often with inadequate dosage and that im...